Our Solution: Noneluting Heparin Coating Technology 

Our noneluting heparin coating covers the external surface of the catheter from tip to cuff and internally from tip to adapters — providing total protection. 

The heparin coating has a triple-action formula:

Heparin — Antithrombogenic

Negative charge — Nonthrombogenic

Hydrophilicity — Nonthrombogeni

1.Decreases likelihood of platelet adhesio

In vivo testing demonstrated an 82 percent reduction in thrombus accumulation versus non-coated catheters. In vitro testing showed a 60 percent reduction in platelet adhesion on the surface when compared with noncoated catheters.

2. Inhibits fibrin sheath propagation Supported by in vivo data, the noneluting heparin coating has been shown to inhibit fibrin sheath propagation when compared with noncoated catheters.

3. Demonstrates long-lasting effectiveness Tested in a shear flow model, the heparin coating remained intact after 720 hours of continuous flow, simulating 12 months of dialysis treatment.

Internal testing shows that the noneluting heparin coating decreases the likelihood of platelet adhesion and inhibits fibrin sheath propagation.

The Clinical Challenge: Thrombosis 

Catheter thrombosis can present challenges, including:

• As many as 40 percent of catheter failures are attributed to venous thrombosis and fibrin sheath formation.
• Approximately 17–33 percent of catheter removals are attributed to thrombosis.
• Complications from thrombosis result in inadequate flow rates, longer dialysis times, and increased costs.

The Palindrome™ Precision HSI chronic catheter with heparin coating and silver ion subcutaneous sleeve is intended for acute and chronic hemodialysis, apheresis, and infusion. It may be inserted either percutaneously or by cutdown.

The device is contraindicated in thrombosed vessels or for subclavian puncture when ventilator is in use. This product should not be used in patients with documented hypersensitivity to silver, heparin or porcine based products. Heparin coated catheters should not be used in patients with severe thrombocytopenia, uncontrollable active bleeding disorders, or with skin necrosis from previous heparin use.  In case of infection, the silver in the catheter does not replace the need for using systemic anti-infective agents. Clinicians/healthcare professionals should be aware that there are very limited data on prolonged and repeated use of silver containing products and particularly in children and neonates.